Dataset Information

Extracellular MRP8/14 is a regulator of ?2 integrin-dependent neutrophil slow rolling and adhesion.

ABSTRACT: Myeloid-related proteins (MRPs) 8 and 14 are cytosolic proteins secreted from myeloid cells as proinflammatory mediators. Currently, the functional role of circulating extracellular MRP8/14 is unclear. Our present study identifies extracellular MRP8/14 as an autocrine player in the leukocyte adhesion cascade. We show that E-selectin-PSGL-1 interaction during neutrophil rolling triggers Mrp8/14 secretion. Released MRP8/14 in turn activates a TLR4-mediated, Rap1-GTPase-dependent pathway of rapid ?2 integrin activation in neutrophils. This extracellular activation loop reduces leukocyte rolling velocity and stimulates adhesion. Thus, we identify Mrp8/14 and TLR4 as important modulators of the leukocyte recruitment cascade during inflammation in vivo.

SUBMITTER: Pruenster M

PROVIDER: S-EPMC4411303 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion.

Pruenster Monika M Kurz Angela R M AR Chung Kyoung-Jin KJ Cao-Ehlker Xiao X Bieber Stephanie S Nussbaum Claudia F CF Bierschenk Susanne S Eggersmann Tanja K TK Rohwedder Ina I Heinig Kristina K Immler Roland R Moser Markus M Koedel Uwe U Gran Sandra S McEver Rodger P RP Vestweber Dietmar D Verschoor Admar A Leanderson Tomas T Chavakis Triantafyllos T Roth Johannes J Vogl Thomas T Sperandio Markus M

Nature communications 20150420

Myeloid-related proteins (MRPs) 8 and 14 are cytosolic proteins secreted from myeloid cells as proinflammatory mediators. Currently, the functional role of circulating extracellular MRP8/14 is unclear. Our present study identifies extracellular MRP8/14 as an autocrine player in the leukocyte adhesion cascade. We show that E-selectin-PSGL-1 interaction during neutrophil rolling triggers Mrp8/14 secretion. Released MRP8/14 in turn activates a TLR4-mediated, Rap1-GTPase-dependent pathway of rapid β ...[more]

PMID: 25892652

Dataset Information

Extracellular MRP8/14 is a regulator of ?2 integrin-dependent neutrophil slow rolling and adhesion.

Publications

Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion.

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