Pharmacogenomics of cisplatin sensitivity in non-small cell lung cancer.
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ABSTRACT:
SUBMITTER: Rose MC
PROVIDER: S-EPMC4411417 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
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Pharmacogenomics of cisplatin sensitivity in non-small cell lung cancer.
Rose Maimon C MC Kostyanovskaya Elina E Huang R Stephanie RS
Genomics, proteomics & bioinformatics 20141028 5
Cisplatin, a platinum-based chemotherapeutic drug, has been used for over 30 years in a wide variety of cancers with varying degrees of success. In particular, cisplatin has been used to treat late stage non-small cell lung cancer (NSCLC) as the standard of care. However, therapeutic outcomes vary from patient to patient. Considerable efforts have been invested to identify biomarkers that can be used to predict cisplatin sensitivity in NSCLC. Here we reviewed current evidence for cisplatin sensi ...[more]
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