Ontology highlight
ABSTRACT:
SUBMITTER: Bottger F
PROVIDER: S-EPMC6581744 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Böttger Franziska F Semenova Ekaterina A EA Song Ji-Ying JY Ferone Giustina G van der Vliet Jan J Cozijnsen Miranda M Bhaskaran Rajith R Bombardelli Lorenzo L Piersma Sander R SR Pham Thang V TV Jimenez Connie R CR Berns Anton A
Cell reports 20190601 11
Small-cell lung cancer is the most aggressive type of lung cancer, characterized by a remarkable response to chemotherapy followed by development of resistance. Here, we describe SCLC subtypes in Mycl- and Nfib-driven GEMM that include CDH1-high peripheral primary tumor lesions and CDH1-negative, aggressive intrapulmonary metastases. Cisplatin treatment preferentially eliminates the latter, thus revealing a striking differential response. Using a combined transcriptomic and proteomic approach, w ...[more]