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Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity.

ABSTRACT: Foot-and-mouth disease (FMD) is a highly contagious disease of domestic and wild ruminants that is caused by FMD virus (FMDV). FMD outbreaks have occurred in livestock-containing regions worldwide. Apigenin, which is a flavonoid naturally existing in plant, possesses various pharmacological effects, including anti-inflammatory, anticancer, antioxidant and antiviral activities. Results show that apigenin can inhibit FMDV-mediated cytopathogenic effect and FMDV replication in vitro. Further studies demonstrate the following: (i) apigenin inhibits FMDV infection at the viral post-entry stage; (ii) apigenin does not exhibit direct extracellular virucidal activity; and (iii) apigenin interferes with the translational activity of FMDV driven by internal ribosome entry site. Studies on applying apigein in vivo are required for drug development and further identification of potential drug targets against FDMV infection.

SUBMITTER: Qian S

PROVIDER: S-EPMC4411668 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity.

Qian Suhong S Fan Wenchun W Qian Ping P Zhang Dong D Wei Yurong Y Chen Huanchun H Li Xiangmin X

Viruses 20150331 4

Foot-and-mouth disease (FMD) is a highly contagious disease of domestic and wild ruminants that is caused by FMD virus (FMDV). FMD outbreaks have occurred in livestock-containing regions worldwide. Apigenin, which is a flavonoid naturally existing in plant, possesses various pharmacological effects, including anti-inflammatory, anticancer, antioxidant and antiviral activities. Results show that apigenin can inhibit FMDV-mediated cytopathogenic effect and FMDV replication in vitro. Further studie ...[more]

PMID: 25835532

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