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An alternative to the Sandmeyer approach to aryl iodides.

ABSTRACT: Iodoarenes are important synthons for a wide range of organic transformations. Here we report a general strategy to prepare singly iodinated electron-rich aromatic compounds through the intermediacy of diaryliodonium salts. This process, which incorporates a phase separation that greatly simplifies product purification, is an attractive replacement for the Sandmeyer approach to iodoarenes that are otherwise difficult to access.

SUBMITTER: Hu B

PROVIDER: S-EPMC4412146 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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An alternative to the Sandmeyer approach to aryl iodides.

Hu Bao B Miller William H WH Neumann Kiel D KD Linstad Ethan J EJ DiMagno Stephen G SG

Chemistry (Weinheim an der Bergstrasse, Germany) 20150310 17

Iodoarenes are important synthons for a wide range of organic transformations. Here we report a general strategy to prepare singly iodinated electron-rich aromatic compounds through the intermediacy of diaryliodonium salts. This process, which incorporates a phase separation that greatly simplifies product purification, is an attractive replacement for the Sandmeyer approach to iodoarenes that are otherwise difficult to access. ...[more]

PMID: 25757054

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