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Carbonylative cross-coupling of ortho-disubstituted aryl iodides. convenient synthesis of sterically hindered aryl ketones.
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ABSTRACT:
SUBMITTER: O'Keefe BM
PROVIDER: S-EPMC2636973 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Carbonylative cross-coupling of ortho-disubstituted aryl iodides. convenient synthesis of sterically hindered aryl ketones.
Organic letters 20081024 22
A mild and general protocol for the carbonylative cross-coupling of sterically hindered ortho-disubstituted aryl iodides is reported. Carbonylative Suzuki-Miyaura couplings of a variety of aryl boronic acids provide an array of substituted biaryl ketones in modest to excellent yield. A carbonylative Negishi coupling that utilizes alkynyl nucleophiles is also described. ...[more]