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Human olfactory receptor responses to odorants.


ABSTRACT: Although the human olfactory system is capable of discriminating a vast number of odors, we do not currently understand what chemical features are encoded by olfactory receptors. In large part this is due to a paucity of data in a search space covering the interactions of hundreds of receptors with billions of odorous molecules. Of the approximately 400 intact human odorant receptors, only 10% have a published ligand. Here we used a heterologous luciferase assay to screen 73 odorants against a clone library of 511 human olfactory receptors. This dataset will allow other researchers to interrogate the combinatorial nature of olfactory coding.

SUBMITTER: Mainland JD 

PROVIDER: S-EPMC4412152 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Human olfactory receptor responses to odorants.

Mainland Joel D JD   Li Yun R YR   Zhou Ting T   Liu Wen Ling L WL   Matsunami Hiroaki H  

Scientific data 20150203


Although the human olfactory system is capable of discriminating a vast number of odors, we do not currently understand what chemical features are encoded by olfactory receptors. In large part this is due to a paucity of data in a search space covering the interactions of hundreds of receptors with billions of odorous molecules. Of the approximately 400 intact human odorant receptors, only 10% have a published ligand. Here we used a heterologous luciferase assay to screen 73 odorants against a c  ...[more]

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