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Human olfactory receptor responses to odorants.

ABSTRACT: Although the human olfactory system is capable of discriminating a vast number of odors, we do not currently understand what chemical features are encoded by olfactory receptors. In large part this is due to a paucity of data in a search space covering the interactions of hundreds of receptors with billions of odorous molecules. Of the approximately 400 intact human odorant receptors, only 10% have a published ligand. Here we used a heterologous luciferase assay to screen 73 odorants against a clone library of 511 human olfactory receptors. This dataset will allow other researchers to interrogate the combinatorial nature of olfactory coding.

SUBMITTER: Mainland JD

PROVIDER: S-EPMC4412152 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Human olfactory receptor responses to odorants.

Mainland Joel D JD Li Yun R YR Zhou Ting T Liu Wen Ling L WL Matsunami Hiroaki H

Scientific data 20150203

Although the human olfactory system is capable of discriminating a vast number of odors, we do not currently understand what chemical features are encoded by olfactory receptors. In large part this is due to a paucity of data in a search space covering the interactions of hundreds of receptors with billions of odorous molecules. Of the approximately 400 intact human odorant receptors, only 10% have a published ligand. Here we used a heterologous luciferase assay to screen 73 odorants against a c ...[more]

PMID: 25977809

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