Ontology highlight
ABSTRACT:
SUBMITTER: Lara-Astiaso D
PROVIDER: S-EPMC4412442 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20140807 6199
Chromatin modifications are crucial for development, yet little is known about their dynamics during differentiation. Hematopoiesis provides a well-defined model to study chromatin state dynamics; however, technical limitations impede profiling of homogeneous differentiation intermediates. We developed a high-sensitivity indexing-first chromatin immunoprecipitation approach to profile the dynamics of four chromatin modifications across 16 stages of hematopoietic differentiation. We identify 48,4 ...[more]