Ontology highlight
ABSTRACT:
SUBMITTER: Neumann M
PROVIDER: S-EPMC4413615 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Neumann Martin M Vosberg Sebastian S Schlee Cornelia C Heesch Sandra S Schwartz Stefan S Gökbuget Nicola N Hoelzer Dieter D Graf Alexander A Krebs Stefan S Bartram Isabelle I Blum Helmut H Brüggemann Monika M Hecht Jochen J Bohlander Stefan K SK Greif Philipp A PA Baldus Claudia D CD
Oncotarget 20150201 5
Novel target discovery is warranted to improve treatment in adult T-cell acute lymphoblastic leukemia (T-ALL) patients. We provide a comprehensive study on mutations to enhance the understanding of therapeutic targets and studied 81 adult T-ALL patients. NOTCH1 exhibitedthe highest mutation rate (53%). Mutation frequencies of FBXW7 (10%), WT1 (10%), JAK3 (12%), PHF6 (11%), and BCL11B (10%) were in line with previous reports. We identified recurrent alterations in transcription factors DNM2, and ...[more]