Ontology highlight
ABSTRACT:
SUBMITTER: Cheng TM
PROVIDER: S-EPMC4413874 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
eLife 20150429
Mitotic chromosomes were one of the first cell biological structures to be described, yet their molecular architecture remains poorly understood. We have devised a simple biophysical model of a 300 kb-long nucleosome chain, the size of a budding yeast chromosome, constrained by interactions between binding sites of the chromosomal condensin complex, a key component of interphase and mitotic chromosomes. Comparisons of computational and experimental (4C) interaction maps, and other biophysical fe ...[more]