Ontology highlight
ABSTRACT:
SUBMITTER: Oudart JB
PROVIDER: S-EPMC4414144 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Oudart Jean-Baptiste JB Brassart-Pasco Sylvie S Vautrin Alexia A Sellier Christèle C Machado Carine C Dupont-Deshorgue Aurelie A Brassart Bertrand B Baud S S Dauchez Manuel M Monboisse Jean-Claude JC Harakat Dominique D Maquart François-Xavier FX Ramont Laurent L
Oncotarget 20150201 6
During tumor invasion, tumor cells degrade the extracellular matrix. Basement membrane degradation is responsible for the production of peptides with anti-tumor properties. Type XIX collagen is associated with basement membranes in vascular, neuronal, mesenchymal and epithelial tissues. Previously, we demonstrated that the non-collagenous NC1, C-terminal, domain of collagen XIX [NC1(XIX)] inhibits the migration capacities of tumor cells and exerts a strong inhibition of tumor growth. Here, we de ...[more]