Ontology highlight
ABSTRACT:
SUBMITTER: Ke J
PROVIDER: S-EPMC4414148 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Ke Jia J Zhao Zhiju Z Hong Su-Hyung SH Bai Shoumin S He Zhen Z Malik Fayaz F Xu Jiahui J Zhou Lei L Chen Weilong W Martin-Trevino Rachel R Wu Xiaojian X Lan Ping P Yi Yongju Y Ginestier Christophe C Ibarra Ingrid I Shang Li L McDermott Sean S Luther Tahra T Clouthier Shawn G SG Wicha Max S MS Liu Suling S
Oncotarget 20150201 6
Increasing evidence suggests that lineage specific subpopulations and stem-like cells exist in normal and malignant breast tissues. Epigenetic mechanisms maintaining this hierarchical homeostasis remain to be investigated. In this study, we found the level of microRNA221 (miR-221) was higher in stem-like and myoepithelial cells than in luminal cells isolated from normal and malignant breast tissue. In normal breast cells, over-expression of miR-221 generated more myoepithelial cells whereas knoc ...[more]