Ontology highlight
ABSTRACT:
SUBMITTER: Lo Vasco VR
PROVIDER: S-EPMC4414842 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Lo Vasco V R VR Leopizzi M M Della Rocca C C
Journal of cell communication and signaling 20150125 1
Selected Phosphoinositide-specific Phospholipase C (PI-PLC) enzymes occupy the convergence point of the broad range of pathways that promote Rho and Ras GTPase mediated signalling, which also regulate the activation of ezrin, a member of the ezrin-radixin-moesin (ERM) proteins family involved in the metastatic osteosarcoma spread. Previous studies described that in distinct human osteosarcoma cell lines ezrin networks the PI-PLC with complex interplay controlling the expression of the PLC genes, ...[more]