Ontology highlight
ABSTRACT: Background
Migration and invasion are two crucial steps of tumor metastasis. Blockage of these steps may be an effective strategy to reduce the risk. The objective of the present study was to investigate the effects of diallyl trisulfide (DATS), a natural organosulfuric compound with most sulfur atoms found in garlic, on migration and invasion in triple negative breast cancer (TNBC) cells. Molecular mechanisms underlying the anticancer effects of DATS were further investigated.Methods and results
MDA-MB-231 cells and HS 578t breast cancer cells were treated with different concentrations of DATS. DATS obviously suppressed the migration and invasion of two cell lines and changed the morphological. Moreover, DATS inhibited the mRNA/protein/ enzymes activities of MMP2/9 via attenuating the NF-?B pathway. DATS also inhibited ERK/MAPK rather than p38 and JNK.Conclusion
DATS inhibits MMP2/9 activity and the metastasis of TNBC cells, and emerges as a potential anti-cancer agent. The inhibitory effects are associated with down-regulation of the transcriptional activities of NF-?B and ERK/MAPK signaling pathways.
SUBMITTER: Liu Y
PROVIDER: S-EPMC4415928 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Liu Yuping Y Zhu Pingting P Wang Yingyu Y Wei Zhonghong Z Tao Li L Zhu Zhijie Z Sheng Xiaobo X Wang Siliang S Ruan Junshan J Liu Zhaoguo Z Cao Yuzhu Y Shan Yunlong Y Sun Lihua L Wang Aiyun A Chen Wenxing W Lu Yin Y
PloS one 20150430 4
<h4>Background</h4>Migration and invasion are two crucial steps of tumor metastasis. Blockage of these steps may be an effective strategy to reduce the risk. The objective of the present study was to investigate the effects of diallyl trisulfide (DATS), a natural organosulfuric compound with most sulfur atoms found in garlic, on migration and invasion in triple negative breast cancer (TNBC) cells. Molecular mechanisms underlying the anticancer effects of DATS were further investigated.<h4>Method ...[more]