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Alteration of gene expression by diallyl trisulfide (DATS) administration in chemically-induced rat mammary tumors

ABSTRACT: We report altered gene expression profiles by DATS in chemically-induced rat mammary tumors

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE189640 | GEO | 2021/12/03

REPOSITORIES: GEO

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Alteration of gene expression by diallyl trisulfide (DATS) administration in chemically-induced rat mammary tumors

Project description:Alteration of gene expression by diallyl trisulfide (DATS) administration in chemically-induced rat mammary tumors

| PRJNA783932 | ENA

Gene Expression Changes by Diallyl Trisulfide Administration in Chemically-induced Mammary Tumors in Rats.

Project description:Diallyl trisulfide (DATS) was shown to be a potent inhibitor of luminal-type MCF-7 xenograft growth in vivo. The present study was conducted to determine the preventive effect of DATS administration using an N-methyl-N-nitrosourea (MNU)-induced rat mammary tumor model, which shares molecular resemblance to luminal-type human breast cancers. The DATS administration (50 mg/kg body weight, 5 times/week) was safe, but did not reduce mammary tumor latency, incidence, burden or multiplicity. Therefore, we conducted RNA-seq analysis using mammary tumors from control and DATS-treated rats (n = 3 for each group) to gain insights into lack of mammary tumor prevention by this phytochemical. The gene ontology and the Kyoto encyclopedia of genes and genomes pathway analyses of the RNA-seq data revealed upregulation of genes associated with ribosomes, translation, peptide biosynthetic/metabolic process, and oxidative phosphorylation but downregulation of genes associated with mitogen-activated protein kinases. A total of 33 genes associated with ribosomes were significantly upregulated by DATS treatment, including RPL11 and RPS14. Western blotting confirmed upregulation of RPL11 and neurofascin protein expression in mammary tumors from DATS-treated rats when compared to controls. A statistically significant increase in protein level of c-Jun N-terminal kinase 2 was also observed in tumors from DATS-treated rats when compared to controls. On the other hand, expression of complex I subunits NDUFV1 or NDUFS1 was not affected by DATS treatment. These results offer potential explanations for ineffectiveness of DATS in the chemically-induced rat mammary tumor model. Inhibitors of the proteins upregulated by DATS may be needed to improve chemopreventive efficacy of this phytochemical.

| S-EPMC8984650 | biostudies-literature

Rat mammary normal - tumor

Project description:Rat mammary tumors induced by N-methyl-N-nitrosurea (NMU) and normal mammary gland Keywords = breast cancer Keywords = rat mammary tumor Keywords = NMU Keywords = animal model. Keywords: other

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Maternal Western-style diet alters the transcriptome of chemically induced mammary tumors in female offspring rats

Project description:Some previous experimental studies have shown that early in life intake of high-fat or Western-style diets did alter the development of mammary cancer in adulthood female rats. Thus, the present study investigated the distinct gene expression patterns of chemically induced mammary tumors derived from female offspring whose dams intake control diet (CD) or Western-style diet (WD). During gestational days (GD) 12-21 and post-natal days (PND) 1-21, pregnant Sprague-Dawley (SD) rats were fed a CD diet or WD (high-fat and low-fiber and oligoelements) diet. On postnatal day (PND) 21, the female offspring received a single dose of carcinogen N-Methyl-N-Nitrosourea (MNU, 50 mg/kg) and CD diet for 12 weeks. Latency, incidence and tumor burden were registered. Mammary tumors samples were collected and histopathology and gene expression analysis were performed.

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Global DNA methylation profiling of radiation-induced rat mammary carcinomas

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Global gene expression profiling of radiation-induced rat mammary carcinomas

Project description:To investigate gene expression patterns in rat mammary carcinomas induced by ionizing radiation.

2018-02-14 | GSE96085 | GEO

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