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Genetic variation within the histamine pathway among patients with asthma--a pilot study.


ABSTRACT: OBJECTIVE:Histamine is an important mediator in the pathophysiology of asthma. We have previously reported that HRH1 is differentially expressed among those with asthma compared to those without asthma. Single histamine-related genes have also been associated with asthma. We aimed to evaluate known single nucleotide polymorphisms (SNPs) in genes along the histamine biotransformation and response pathway, and determine their association with asthma and HRH1 mRNA expression. METHODS:We enrolled children and adults (n?=?93) with/without asthma who met inclusion/exclusion criteria. Genotyping was performed for nine known SNPs in the HDC, HRH1, HRH4, HNMT and ABP1 genes. HRH1 mRNA expression was determined on RNA from buccal tissue. General linear model, Fisher's exact test and Chi-square test were used to determine differences in allele, genotype and haplotype frequency between subjects with and without asthma and differential HRH1 mRNA expression relative to genotype. Statistical significance was determined by p?

SUBMITTER: Raje N 

PROVIDER: S-EPMC4416071 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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Genetic variation within the histamine pathway among patients with asthma--a pilot study.

Raje Nikita N   Vyhlidal Carrie A CA   Dai Hongying H   Jones Bridgette L BL  

The Journal of asthma : official journal of the Association for the Care of Asthma 20141030 4


<h4>Objective</h4>Histamine is an important mediator in the pathophysiology of asthma. We have previously reported that HRH1 is differentially expressed among those with asthma compared to those without asthma. Single histamine-related genes have also been associated with asthma. We aimed to evaluate known single nucleotide polymorphisms (SNPs) in genes along the histamine biotransformation and response pathway, and determine their association with asthma and HRH1 mRNA expression.<h4>Methods</h4  ...[more]

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