Genetic Variation along the Histamine Pathway in Children with Allergic versus Nonallergic Asthma.

ABSTRACT: Histamine is an important mediator in the pathogenesis of asthma. Variation in genes along the histamine production, response, and degradation pathway may be important in predicting response to antihistamines. We hypothesize that differences exist among single-nucleotide polymorphisms (SNPs) in genes of the histamine pathway between children with allergic versus nonallergic asthma. Children (7-18 yr of age; n?=?202) with asthma were classified as allergic or nonallergic based on allergy skin testing. Genotyping was performed to detect known SNPs (n?=?10) among genes (HDC, HNMT, ABP1, HRH1, and HRH4) within the histamine pathway. Chi square tests and Cochran-Armitage Trend were used to identify associations between genetic variants and allergic or nonallergic asthma. Significance was determined by P?

SUBMITTER: Anvari S 

PROVIDER: S-EPMC4742940 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature