Ontology highlight
ABSTRACT:
SUBMITTER: Tan SH
PROVIDER: S-EPMC441609 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Tan Soon-Heng SH Zhang Zhuo Z Ng See-Kiong SK
Nucleic acids research 20040701 Web Server issue
ADVICE (Automated Detection and Validation of Interaction by Co-Evolution) is a web tool for predicting and validating protein-protein interactions using the observed co-evolution between interacting proteins. Interacting proteins are known to share similar evolutionary histories since they undergo coordinated evolutionary changes to preserve interactions and functionalities. The web tool automates a commonly adopted methodology to quantify the similarities in proteins' evolutionary histories fo ...[more]