Discovery of a Small-Molecule Probe for V-ATPase Function.

ABSTRACT: Lysosomes perform a critical cellular function as a site of degradation for diverse cargoes including proteins, organelles, and pathogens delivered through distinct pathways, and defects in lysosomal function have been implicated in a number of diseases. Recent studies have elucidated roles for the lysosome in the regulation of protein synthesis, metabolism, membrane integrity, and other processes involved in homeostasis. Complex small-molecule natural products have greatly contributed to the investigation of lysosomal function in cellular physiology. Here we report the discovery of a novel, small-molecule modulator of lysosomal acidification derived from diversity-oriented synthesis through high-content screening.

SUBMITTER: Aldrich LN 

PROVIDER: S-EPMC4416280 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature