Ontology highlight
ABSTRACT:
SUBMITTER: Gerasimcik N
PROVIDER: S-EPMC4416737 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Gerasimcik Natalija N Dahlberg Carin I M CI Baptista Marisa A P MA Massaad Michel J MJ Geha Raif S RS Westerberg Lisa S LS Severinson Eva E
Journal of immunology (Baltimore, Md. : 1950) 20150413 10
The Rho GTPase Cdc42 coordinates regulation of the actin and the microtubule cytoskeleton by binding and activating the Wiskott-Aldrich syndrome protein. We sought to define the role of intrinsic expression of Cdc42 by mature B cells in their activation and function. Mice with inducible deletion of Cdc42 in mature B cells formed smaller germinal centers and had a reduced Ab response, mostly of low affinity to T cell-dependent Ag, compared with wild-type (WT) controls. Spreading formation of long ...[more]