Ontology highlight
ABSTRACT:
SUBMITTER: Francy CA
PROVIDER: S-EPMC4416870 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Francy Christopher A CA Alvarez Frances J D FJ Zhou Louie L Ramachandran Rajesh R Mears Jason A JA
The Journal of biological chemistry 20150313 18
Mitochondria are dynamic organelles that continually undergo cycles of fission and fusion. Dynamin-related protein 1 (Drp1), a large GTPase of the dynamin superfamily, is the main mediator of mitochondrial fission. Like prototypical dynamin, Drp1 is composed of a mechanochemical core consisting of the GTPase, middle, and GTPase effector domain regions. In place of the pleckstrin homology domain in dynamin, however, Drp1 contains an unstructured variable domain, whose function is not yet fully re ...[more]