Ontology highlight
ABSTRACT:
SUBMITTER: Porciani D
PROVIDER: S-EPMC4417125 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Porciani David D Tedeschi Lorena L Marchetti Laura L Citti Lorenzo L Piazza Vincenzo V Beltram Fabio F Signore Giovanni G
Molecular therapy. Nucleic acids 20150428
Aptamers able to bind efficiently cell-surface receptors differentially expressed in tumor and in healthy cells are emerging as powerful tools to perform targeted anticancer therapy. Here, we present a novel oligonucleotide chimera, composed by an RNA aptamer and a DNA decoy. Our assembly is able to (i) target tumor cells via an antitransferrin receptor RNA aptamer and (ii) perform selective codelivery of a chemotherapeutic drug (Doxorubicin) and of an inhibitor of a cell-survival factor, the nu ...[more]