Ontology highlight
ABSTRACT:
SUBMITTER: Ju HQ
PROVIDER: S-EPMC5684443 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Ju H-Q HQ Lu Y-X YX Wu Q-N QN Liu J J Zeng Z-L ZL Mo H-Y HY Chen Y Y Tian T T Wang Y Y Kang T-B TB Xie D D Zeng M-S MS Huang P P Xu R-H RH
Oncogene 20170710 45
Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme that generates NADPH to maintain reduced glutathione (GSH), which scavenges reactive oxygen species (ROS) to protect cancer cell from oxidative damage. In this study, we mainly investigate the potential roles of G6PD in colorectal cancer (CRC) development and chemoresistance. We discover that G6PD is overexpressed in CRC cells and patient specimens. High expression of G6PD predicts poor prognosis and correlated with poor outcome of oxalipl ...[more]