Ontology highlight
ABSTRACT:
SUBMITTER: Iyer MK
PROVIDER: S-EPMC4417758 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Iyer Matthew K MK Niknafs Yashar S YS Malik Rohit R Singhal Udit U Sahu Anirban A Hosono Yasuyuki Y Barrette Terrence R TR Prensner John R JR Evans Joseph R JR Zhao Shuang S Poliakov Anton A Cao Xuhong X Dhanasekaran Saravana M SM Wu Yi-Mi YM Robinson Dan R DR Beer David G DG Feng Felix Y FY Iyer Hariharan K HK Chinnaiyan Arul M AM
Nature genetics 20150119 3
Long noncoding RNAs (lncRNAs) are emerging as important regulators of tissue physiology and disease processes including cancer. To delineate genome-wide lncRNA expression, we curated 7,256 RNA sequencing (RNA-seq) libraries from tumors, normal tissues and cell lines comprising over 43 Tb of sequence from 25 independent studies. We applied ab initio assembly methodology to this data set, yielding a consensus human transcriptome of 91,013 expressed genes. Over 68% (58,648) of genes were classified ...[more]