Ontology highlight
ABSTRACT:
SUBMITTER: Carbajal-Franco E
PROVIDER: S-EPMC4418002 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Carbajal-Franco Ebzadrel E de la Fuente-Granada Marisol M Alemán-Muench Germán R GR García-Zepeda Eduardo A EA Soldevila Gloria G
Journal of immunology research 20150420
Inhibins and Activins are members of the TGF-β superfamily that regulate the differentiation of several cell types. These ligands were initially identified as hormones that regulate the hypothalamus-pituitary-gonadal axis; however, increasing evidence has demonstrated that they are key regulators in the immune system. We have previously demonstrated that Inhibins are the main Activin ligands expressed in the murine thymus and that they regulate thymocyte differentiation, promoting the DN3-DN4 tr ...[more]