Ontology highlight
ABSTRACT:
SUBMITTER: Solanki A
PROVIDER: S-EPMC5817998 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Solanki Anisha A Yanez Diana C DC Ross Susan S Lau Ching-In CI Papaioannou Eleftheria E Li Jiawei J Saldaña José Ignacio JI Crompton Tessa T
Development (Cambridge, England) 20180131 3
Gli3 is a Hedgehog (Hh)-responsive transcription factor that can function as a transcriptional repressor or activator. We show that Gli3 activity in mouse thymic epithelial cells (TECs) promotes positive selection and differentiation from CD4<sup>+</sup> CD8<sup>+</sup> to CD4<sup>+</sup> CD8<sup>-</sup> single-positive (SP4) cells in the fetal thymus and that Gli3 represses <i>Shh</i> Constitutive deletion of <i>Gli3</i>, and conditional deletion of <i>Gli3</i> from TECs, reduced differentiatio ...[more]