Ontology highlight
ABSTRACT:
SUBMITTER: Ganji RJ
PROVIDER: S-EPMC4420530 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Ganji Roopa Jones RJ Reddi Ravikumar R Gumpena Rajesh R Marapaka Anil Kumar AK Arya Tarun T Sankoju Priyanka P Bhukya Supriya S Addlagatta Anthony A
Protein science : a publication of the Protein Society 20150408 5
Actinonin is a pseudotripeptide that displays a high affinity towards metalloproteases including peptide deformylases (PDFs) and M1 family aminopeptidases. PDF and M1 family aminopeptidases belong to thermolysin-metzincin superfamily. One of the major differences in terms of substrate binding pockets between these families is presence (in M1 aminopeptidases) or absence (in PDFs) of an S1 substrate pocket. The binding mode of actinonin to PDFs has been established previously; however, it is not c ...[more]