Ontology highlight
ABSTRACT:
SUBMITTER: Salomon E
PROVIDER: S-EPMC6222927 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Salomon Emmanuel E Schmitt Marjorie M Marapaka Anil Kumar AK Stamogiannos Athanasios A Revelant Germain G Schmitt Céline C Alavi Sarah S Florent Isabelle I Addlagatta Anthony A Stratikos Efstratios E Tarnus Céline C Albrecht Sébastien S
Molecules (Basel, Switzerland) 20181011 10
The synthesis of racemic substituted 7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-one hydrochlorides was optimized to enhance reproducibility and increase the overall yield. In order to investigate their specificity, series of enzyme inhibition assays were carried out against a diversity of proteases, covering representative members of aspartic, cysteine, metallo and serine endopeptidases and including eight members of the monometallic M1 family of aminopeptidases as well as two members of the b ...[more]