Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with 18F-ML-8.
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ABSTRACT:
SUBMITTER: Yao S
PROVIDER: S-EPMC4420799 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with 18F-ML-8.
Yao Shaobo S Hu Kongzhen K Tang Ganghua G Gao Siyuan S Tang Caihua C Yao Baoguo B Nie Dahong D Sun Ting T Jiang Shende S
BioMed research international 20150409
In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The experimental result is further confirmed by in vitro cell binding assays and TUNEL staining assay. As a result, (18)F-ML-8 could be used for noninvasive visualization of apoptosis ind ...[more]
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