Ontology highlight
ABSTRACT:
SUBMITTER: Cui J
PROVIDER: S-EPMC4421793 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Cui Jixin J Xiao Junyu J Tagliabracci Vincent S VS Wen Jianzhong J Rahdar Meghdad M Dixon Jack E JE
eLife 20150319
Although numerous extracellular phosphoproteins have been identified, the protein kinases within the secretory pathway have only recently been discovered, and their regulation is virtually unexplored. Fam20C is the physiological Golgi casein kinase, which phosphorylates many secreted proteins and is critical for proper biomineralization. Fam20A, a Fam20C paralog, is essential for enamel formation, but the biochemical function of Fam20A is unknown. Here we show that Fam20A potentiates Fam20C kina ...[more]