Dataset Information

Soft Tissue Deformations Contribute to the Mechanics of Walking in Obese Adults.

ABSTRACT: Obesity not only adds to the mass that must be carried during walking but also changes body composition. Although extra mass causes roughly proportional increases in musculoskeletal loading, less well understood is the effect of relatively soft and mechanically compliant adipose tissue.This purpose of this study was to estimate the work performed by soft tissue deformations during walking. The soft tissue would be expected to experience damped oscillations, particularly from high force transients after heel strike, and could potentially change the mechanical work demands for walking.We analyzed treadmill walking data at 1.25 m·s for 11 obese (BMI >30 kg·m) and nine nonobese (BMI <30 kg·m) adults. The soft tissue work was quantified with a method that compares the work performed by lower extremity joints as derived using assumptions of rigid body segments, with that estimated without rigid body assumptions.Relative to body mass, obese and nonobese individuals perform similar amounts of mechanical work. However, negative work performed by soft tissues was significantly greater in obese individuals (P = 0.0102), equivalent to approximately 0.36 J·kg vs 0.27 J·kg in nonobese individuals. The negative (dissipative) work by soft tissues occurred mainly after heel strike and, for obese individuals, was comparable in magnitude to the total negative work from all of the joints combined (0.34 J·kg vs 0.33 J·kg for obese and nonobese adults, respectively). Although the joints performed a relatively similar amount of work overall, obese individuals performed less negative work actively at the knee.The greater proportion of soft tissues in obese individuals results in substantial changes in the amount, location, and timing of work and may also affect metabolic energy expenditure during walking.

SUBMITTER: Fu XY

PROVIDER: S-EPMC4422789 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Soft Tissue Deformations Contribute to the Mechanics of Walking in Obese Adults.

Fu Xiao-Yu XY Zelik Karl E KE Board Wayne J WJ Browning Raymond C RC Kuo Arthur D AD

Medicine and science in sports and exercise 20150701 7

<h4>Unlabelled</h4>Obesity not only adds to the mass that must be carried during walking but also changes body composition. Although extra mass causes roughly proportional increases in musculoskeletal loading, less well understood is the effect of relatively soft and mechanically compliant adipose tissue.<h4>Purpose</h4>This purpose of this study was to estimate the work performed by soft tissue deformations during walking. The soft tissue would be expected to experience damped oscillations, par ...[more]

PMID: 25380475

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Project description:Background and objectiveTigecycline, a broad-spectrum glycylcycline antibiotic, is approved for use at a fixed dose irrespective of body weight. However, its pharmacokinetics may be altered in obesity, which would impact on the antibiotic's effectiveness. The objective of this study was to investigate the plasma and subcutaneous tissue concentrations of tigecycline in obese patients compared with those in a non-obese control group.MethodsFifteen obese patients (one class II and 14 class III) undergoing bariatric surgery and 15 non-obese patients undergoing intra-abdominal surgery (mainly tumour resection) received a single dose of 50 or 100 mg tigecycline as an intravenous short infusion. Tigecycline concentrations were measured up to 8 h after dosing in plasma (total concentration), in ultrafiltrate of plasma (free concentration), and in microdialysate from subcutaneous tissue, respectively.ResultsIn obese patients, total peak plasma concentration (1.31 ± 0.50 vs 2.27 ± 1.40 mg/L) and the area under the concentration-time curve from 0 to 8 h (AUC8h,plasma: 2.15 ± 0.42 vs 2.74 ± 0.73 h⋅mg/L), as normalized to a 100 mg dose, were significantly lower compared with those of non-obese patients. No significant differences were observed regarding the free plasma concentration, as determined by ultrafiltration, or the corresponding AUC8h (fAUC8h,plasma). Concentrations in interstitial fluid (ISF) of subcutaneous tissue were lower than the free plasma concentrations in both groups, and they were lower in obese compared to non-obese patients: the AUC8h in ISF (AUC8h,ISF) was 0.51 ± 0.22 h⋅mg/L in obese and 0.79 ± 0.23 h⋅mg/L in non-obese patients, resulting in a relative tissue drug exposure (AUC8h,ISF/fAUC8h,plasma) of 0.38 ± 0.19 and 0.63 ± 0.24, respectively.ConclusionFollowing a single dose of tigecycline, concentrations in the ISF of subcutaneous adipose tissue are decreased in heavily obese subjects, calling for an increased loading dose.Eu clinical trials registration numberEudraCT No. 2012-004383-22.

Dataset Information

Soft Tissue Deformations Contribute to the Mechanics of Walking in Obese Adults.

Publications

Soft Tissue Deformations Contribute to the Mechanics of Walking in Obese Adults.

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