Ontology highlight
ABSTRACT:
SUBMITTER: Hertig S
PROVIDER: S-EPMC4423039 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Hertig Samuel S Goddard Thomas D TD Johnson Graham T GT Ferrin Thomas E TE
Biophysical journal 20150501 9
Homology modeling predicts protein structures using known structures of related proteins as templates. We developed MULTIDOMAIN ASSEMBLER (MDA) to address the special problems that arise when modeling proteins with large numbers of domains, such as fibronectin with 30 domains, as well as cases with hundreds of templates. These problems include how to spatially arrange nonoverlapping template structures, and how to get the best template coverage when some sequence regions have hundreds of availab ...[more]