Bioactive oleanane glycosides from Polyscias duplicata from the Madagascar dry forest.

ABSTRACT: As part of the International Cooperative Biodiversity Group (ICBG) program, in a search for antiproliferative compounds, an ethanol extract of Polyscias duplicata was investigated due to its antiproliferative activity against the A2780 human ovarian cell cancer line (IC50 6 µg/mL). Seven known oleanane glycosides, 3?-[(?-L-arabinopyranosyl)oxy]-16?-hydroxyolean-12-en-28-oic acid (1, IC50 8 µM), 3?-[(?-L-arabinopyranosyl)oxy]-16?,23-dihydroxyolean-12-en-18-oic acid (2, IC50 13 µM), 3?-[(O-?-D-glucopyranosyl-(t-->3)-?-L-arabinopyranosyl)oxy]-16?-hydroxyolean-12-en-28-oic acid (3, IC50 7 µM), 3?-[(O-?-L-rhamnopyranosyl-(1-2)-?-L-arabinopyranosyl)oxy]-16?-hydroxyolean-12-en-28-oic acid (4, IC50 2.8 µM), 3?-[(O-?-D-glucopyranosyl-(l-->3)-?-L- arabinopyranosyl)oxy]-23-hydroxyolean-12-en-28-oic acid (5, IC50 10 µM), ?-[(O-?-L-rhamnopyranosyl-(-1.2)-?-L-arabinopyranosyl)oxy]-23-hydroxyolean-12-en-28-oic acid (6, IC50 3.4 µM), and 3?-[(?-L-arabinopyranosyl)oxy]-23-hydroxyolean-12-en-28-oic acid (7, IC50 3.4 µM) were isolated, and their structures determined using spectroscopic methods.

SUBMITTER: Eaton AL 

PROVIDER: S-EPMC4423820 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature