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Cross-kingdom chemical communication drives a heritable, mutually beneficial prion-based transformation of metabolism.


ABSTRACT: In experimental science, organisms are usually studied in isolation, but in the wild, they compete and cooperate in complex communities. We report a system for cross-kingdom communication by which bacteria heritably transform yeast metabolism. An ancient biological circuit blocks yeast from using other carbon sources in the presence of glucose. [GAR(+)], a protein-based epigenetic element, allows yeast to circumvent this "glucose repression" and use multiple carbon sources in the presence of glucose. Some bacteria secrete a chemical factor that induces [GAR(+)]. [GAR(+)] is advantageous to bacteria because yeast cells make less ethanol and is advantageous to yeast because their growth and long-term viability is improved in complex carbon sources. This cross-kingdom communication is broadly conserved, providing a compelling argument for its adaptive value. By heritably transforming growth and survival strategies in response to the selective pressures of life in a biological community, [GAR(+)] presents a unique example of Lamarckian inheritance.

SUBMITTER: Jarosz DF 

PROVIDER: S-EPMC4424051 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Cross-kingdom chemical communication drives a heritable, mutually beneficial prion-based transformation of metabolism.

Jarosz Daniel F DF   Brown Jessica C S JCS   Walker Gordon A GA   Datta Manoshi S MS   Ung W Lloyd WL   Lancaster Alex K AK   Rotem Assaf A   Chang Amelia A   Newby Gregory A GA   Weitz David A DA   Bisson Linda F LF   Lindquist Susan S  

Cell 20140801 5


In experimental science, organisms are usually studied in isolation, but in the wild, they compete and cooperate in complex communities. We report a system for cross-kingdom communication by which bacteria heritably transform yeast metabolism. An ancient biological circuit blocks yeast from using other carbon sources in the presence of glucose. [GAR(+)], a protein-based epigenetic element, allows yeast to circumvent this "glucose repression" and use multiple carbon sources in the presence of glu  ...[more]

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