Ontology highlight
ABSTRACT:
SUBMITTER: Kelley K
PROVIDER: S-EPMC4424061 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Kelley Kotaro K Knockenhauer Kevin E KE Kabachinski Greg G Schwartz Thomas U TU
Nature structural & molecular biology 20150330 5
The nuclear pore complex (NPC) is the principal gateway for transport into and out of the nucleus. Selectivity is achieved through the hydrogel-like core of the NPC. The structural integrity of the NPC depends on ~15 architectural proteins, which are organized in distinct subcomplexes to form the >40-MDa ring-like structure. Here we present the 4.1-Å crystal structure of a heterotetrameric core element ('hub') of the Y complex, the essential NPC building block, from Myceliophthora thermophila. U ...[more]