Ontology highlight
ABSTRACT:
SUBMITTER: Selvan N
PROVIDER: S-EPMC4424335 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Selvan Nithya N Mariappa Daniel D van den Toorn Henk W P HW Heck Albert J R AJ Ferenbach Andrew T AT van Aalten Daan M F DM
The Journal of biological chemistry 20150316 19
Protein O-GlcNAcylation is a reversible post-translational signaling modification of nucleocytoplasmic proteins that is essential for embryonic development in bilateria. In a search for a reductionist model to study O-GlcNAc signaling, we discovered the presence of functional O-GlcNAc transferase (OGT), O-GlcNAcase (OGA), and nucleocytoplasmic protein O-GlcNAcylation in the most basal extant animal, the placozoan Trichoplax adhaerens. We show via enzymatic characterization of Trichoplax OGT/OGA ...[more]