Ontology highlight
ABSTRACT:
SUBMITTER: Chu C
PROVIDER: S-EPMC4425988 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Cell 20150402 2
Noncoding RNAs (ncRNAs) function with associated proteins to effect complex structural and regulatory outcomes. To reveal the composition and dynamics of specific noncoding RNA-protein complexes (RNPs) in vivo, we developed comprehensive identification of RNA binding proteins by mass spectrometry (ChIRP-MS). ChIRP-MS analysis of four ncRNAs captures key protein interactors, including a U1-specific link to the 3' RNA processing machinery. Xist, an essential lncRNA for X chromosome inactivation (X ...[more]