Ontology highlight
ABSTRACT:
SUBMITTER: Lee K
PROVIDER: S-EPMC4426190 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Lee Kyuwan K Cui Yi Y Lee Luke P LP Irudayaraj Joseph J
Nature nanotechnology 20140420 6
Alternative messenger RNA (mRNA) splicing is a fundamental process of gene regulation, and errors in RNA splicing are known to be associated with a variety of different diseases. However, there is currently a lack of quantitative technologies for monitoring mRNA splice variants in cells. Here, we show that a combination of plasmonic dimer probes and hyperspectral imaging can be used to detect and quantify mRNA splice variants in living cells. The probes are made from gold nanoparticles functiona ...[more]