Ontology highlight
ABSTRACT:
SUBMITTER: Neelam S
PROVIDER: S-EPMC4426403 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Neelam Srujana S Chancellor T J TJ Li Yuan Y Nickerson Jeffrey A JA Roux Kyle J KJ Dickinson Richard B RB Lele Tanmay P TP
Proceedings of the National Academy of Sciences of the United States of America 20150421 18
How cells maintain nuclear shape and position against various intracellular and extracellular forces is not well understood, although defects in nuclear mechanical homeostasis are associated with a variety of human diseases. We estimated the force required to displace and deform the nucleus in adherent living cells with a technique to locally pull the nuclear surface. A minimum pulling force of a few nanonewtons--far greater than typical intracellular motor forces--was required to significantly ...[more]