Ontology highlight
ABSTRACT:
SUBMITTER: Rosales AM
PROVIDER: S-EPMC5668133 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Rosales Adrianne M AM Vega Sebastián L SL DelRio Frank W FW Burdick Jason A JA Anseth Kristi S KS
Angewandte Chemie (International ed. in English) 20170901 40
The relationship between ECM mechanics and cell behavior is dynamic, as cells remodel and respond to changes in their local environment. Most in vitro substrates are static and supraphysiologically stiff; thus, platforms with dynamic and reversible mechanical changes are needed. Herein, we developed hyaluronic acid-based substrates capable of sequential photodegradation and photoinitiated crosslinking reactions to soften and then stiffen the hydrogels over a physiologically relevant range of mod ...[more]