Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy.
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ABSTRACT:
SUBMITTER: Desantis A
PROVIDER: S-EPMC4426481 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy.
Desantis Agata A Bruno Tiziana T Catena Valeria V De Nicola Francesca F Goeman Frauke F Iezzi Simona S Sorino Cristina C Ponzoni Maurilio M Bossi Gianluca G Federico Vincenzo V La Rosa Francesca F Ricciardi Maria Rosaria MR Lesma Elena E De Meo Paolo D'Onorio PD Castrignanò Tiziana T Petrucci Maria Teresa MT Pisani Francesco F Chesi Marta M Bergsagel P Leif PL Floridi Aristide A Tonon Giovanni G Passananti Claudio C Blandino Giovanni G Fanciulli Maurizio M
The EMBO journal 20150314 9
Mammalian target of rapamycin (mTOR) is a key protein kinase that regulates cell growth, metabolism, and autophagy to maintain cellular homeostasis. Its activity is inhibited by adverse conditions, including nutrient limitation, hypoxia, and DNA damage. In this study, we demonstrate that Che-1, a RNA polymerase II-binding protein activated by the DNA damage response, inhibits mTOR activity in response to stress conditions. We found that, under stress, Che-1 induces the expression of two importan ...[more]
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