Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC4427571 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Zhao Yuzheng Y Hu Qingxun Q Cheng Feixiong F Su Ni N Wang Aoxue A Zou Yejun Y Hu Hanyang H Chen Xianjun X Zhou Hai-Meng HM Huang Xinzhi X Yang Kai K Zhu Qian Q Wang Xue X Yi Jing J Zhu Linyong L Qian Xuhong X Chen Lixin L Tang Yun Y Loscalzo Joseph J Yang Yi Y
Cell metabolism 20150501 5
The altered metabolism of tumor cells confers a selective advantage for survival and proliferation, and studies have shown that targeting such metabolic shifts may be a useful therapeutic strategy. We developed an intensely fluorescent, rapidly responsive, pH-resistant, genetically encoded sensor of wide dynamic range, denoted SoNar, for tracking cytosolic NAD(+) and NADH redox states in living cells and in vivo. SoNar responds to subtle perturbations of various pathways of energy metabolism in ...[more]