Ontology highlight
ABSTRACT:
SUBMITTER: Gerber PP
PROVIDER: S-EPMC4427790 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Gerber Pehuén Pereyra PP Cabrini Mercedes M Jancic Carolina C Paoletti Luciana L Banchio Claudia C von Bilderling Catalina C Sigaut Lorena L Pietrasanta Lía I LI Duette Gabriel G Freed Eric O EO Basile Genevieve de Saint Gde S Moita Catarina Ferreira CF Moita Luis Ferreira LF Amigorena Sebastian S Benaroch Philippe P Geffner Jorge J Ostrowski Matías M
The Journal of cell biology 20150504 3
During the late stages of the HIV-1 replication cycle, the viral polyprotein Pr55(Gag) is recruited to the plasma membrane (PM), where it binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and directs HIV-1 assembly. We show that Rab27a controls the trafficking of late endosomes carrying phosphatidylinositol 4-kinase type 2 α (PI4KIIα) toward the PM of CD4(+) T cells. Hence, Rab27a promotes high levels of PM phosphatidylinositol 4-phosphate and the localized production of PI(4,5)P2, therefo ...[more]