Ontology highlight
ABSTRACT:
SUBMITTER: Baba T
PROVIDER: S-EPMC6463214 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Baba Takashi T Toth Daniel J DJ Sengupta Nivedita N Kim Yeun Ju YJ Balla Tamas T
The EMBO journal 20190313 8
The small GTPase Rab7 is a key organizer of receptor sorting and lysosomal degradation by recruiting of a variety of effectors depending on its GDP/GTP-bound state. However, molecular mechanisms that trigger Rab7 inactivation remain elusive. Here we find that, among the endosomal pools, Rab7-positive compartments possess the highest level of PI4P, which is primarily produced by PI4K2A kinase. Acute conversion of this endosomal PI4P to PI(4,5)P<sub>2</sub> causes Rab7 dissociation from late endos ...[more]