Ontology highlight
ABSTRACT:
SUBMITTER: Amendola M
PROVIDER: S-EPMC4428043 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Amendola Mario M van Steensel Bas B
EMBO reports 20150317 5
In mammals, the nuclear lamina interacts with hundreds of large genomic regions, termed lamina-associated domains (LADs) that are generally in a transcriptionally repressed state. Lamins form the major structural component of the lamina and have been reported to bind DNA and chromatin. Here, we systematically evaluate whether lamins are necessary for the LAD organization in murine embryonic stem cells. Surprisingly, removal of essentially all lamins does not have any detectable effect on the gen ...[more]