Ontology highlight
ABSTRACT:
SUBMITTER: Barton LJ
PROVIDER: S-EPMC3710436 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Barton Lacy J LJ Pinto Belinda S BS Wallrath Lori L LL Geyer Pamela K PK
Developmental cell 20130601 6
LEM domain (LEM-D) proteins are components of an extensive protein network that assembles beneath the inner nuclear envelope. Defects in LEM-D proteins cause tissue-restricted human diseases associated with altered stem cell homeostasis. Otefin (Ote) is a Drosophila LEM-D protein that is intrinsically required for female germline stem cell (GSC) maintenance. Previous studies linked Ote loss with transcriptional activation of the key differentiation gene bag-of-marbles (bam), leading to the model ...[more]