Ontology highlight
ABSTRACT:
SUBMITTER: Safory H
PROVIDER: S-EPMC4428048 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Safory Hazem H Neame Samah S Shulman Yoav Y Zubedat Salman S Radzishevsky Inna I Rosenberg Dina D Sason Hagit H Engelender Simone S Avital Avi A Hülsmann Swen S Schiller Jackie J Wolosker Herman H
EMBO reports 20150309 5
Asc-1 (SLC7A10) is an amino acid transporter whose deletion causes neurological abnormalities and early postnatal death in mice. Using metabolomics and behavioral and electrophysiological methods, we demonstrate that Asc-1 knockout mice display a marked decrease in glycine levels in the brain and spinal cord along with impairment of glycinergic inhibitory transmission, and a hyperekplexia-like phenotype that is rescued by replenishing brain glycine. Asc-1 works as a glycine and L-serine transpor ...[more]