Ontology highlight
ABSTRACT:
SUBMITTER: Mesuret G
PROVIDER: S-EPMC5986860 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Mesuret Guillaume G Khabbazzadeh Sepideh S Bischoff Anne M AM Safory Hazem H Wolosker Herman H Hülsmann Swen S
Scientific reports 20180604 1
The Alanine-Serine-Cysteine-1 transporter (SLC7A10, Asc-1) has been shown to play a role in synaptic availability of glycine although the exact mechanism remains unclear. We used electrophysiological recordings and biochemical experiments to investigate the role of Asc-1 transporter in glycinergic transmission in the brainstem respiratory network. Using both the Asc-1 substrate and transportable inhibitor D-isoleucine (D-Ile), and the non-transportable Asc-1 blocker Lu AE00527 (Lu), we found tha ...[more]