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Peptide aptamers: development and applications.


ABSTRACT: Peptide aptamers are small combinatorial proteins that are selected to bind to specific sites on their target molecules. Peptide aptamers consist of short, 5-20 amino acid residues long sequences, typically embedded as a loop within a stable protein scaffold. Various peptide aptamer scaffolds and in vitro and in vivo selection techniques are reviewed with emphasis on specific biomedical, bioimaging, and bioanalytical applications.

SUBMITTER: Reverdatto S 

PROVIDER: S-EPMC4428161 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Peptide aptamers: development and applications.

Reverdatto Sergey S   Burz David S DS   Shekhtman Alexander A  

Current topics in medicinal chemistry 20150101 12


Peptide aptamers are small combinatorial proteins that are selected to bind to specific sites on their target molecules. Peptide aptamers consist of short, 5-20 amino acid residues long sequences, typically embedded as a loop within a stable protein scaffold. Various peptide aptamer scaffolds and in vitro and in vivo selection techniques are reviewed with emphasis on specific biomedical, bioimaging, and bioanalytical applications. ...[more]

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