Ontology highlight
ABSTRACT:
SUBMITTER: Arabacilar P
PROVIDER: S-EPMC4428223 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Arabacilar Pelin P Marber Michael M
Frontiers in pharmacology 20150512
This minireview discusses the evidence that the inhibition of p38 mitogen-activated protein kinases (p38 MAPKs) maybe of therapeutic value in heart failure. Most previous experimental studies, as well as past and ongoing clinical trials, have focussed on the role of p38 MAPKs in myocardial infarction and acute coronary syndromes. There is now growing evidence that these kinases are activated within the myocardium of the failing human heart and in the heart and blood vessels of animal models of h ...[more]